WHERE IS THE RISK REWARD? THE IMPACT OF VOLATILITY-BASED FUND CLASSIFICATION ON PERFORMANCE


A Pharmacovigilance Approach for Post-Marketing in Japan Using the Japanese Adverse Drug Event Report (JADER) Database and Association Analysis.

BACKGROUND:Rapid dissemination of information regarding adverse drug reactions is a key aspect for improving pharmacovigilance.There is a possibility that unknown adverse drug reactions will become apparent through post-marketing administration.Currently, although there have been studies evaluating the relationships between a drug and adverse drug

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Gasdermin D mediates endoplasmic reticulum stress via FAM134B to regulate cardiomyocyte autophagy and apoptosis in doxorubicin-induced cardiotoxicity

Abstract Cardiomyocyte pyroptosis and apoptosis play a vital role in the pathophysiology of several cardiovascular diseases.Our recent study revealed that gasdermin D (GSDMD) can promote myocardial I/R injury via the caspase-11/GSDMD pathway.We also found that GSDMD deletion attenuated myocardial I/R and MI injury by reducing cardiomyocyte apoptosi

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